Alzheimer''s disease

People with Alzheimer’s disease have dementia which occurs when healthy, brain tissue degenerates, causing a steady decline in memory and mental abilities.
Late evening tends to lead to confusion.
Most people with Alzheimer’s are unable to cope with unexpected events or a change in their regular schedule. Changing their surroundings can send them into a very unstable since of security.

Also a predominate change in mood and personality, disorientation to place, time, date or event. They also have a loss of judgment or decision making ability.